Thrombogenicity in Different Types of Drug-Eluting Stents During Transition from Dual to Single Antiplatelet Therapy

Dual antiplatelet therapy (DPT) is the combination of two medications used to prevent blood clots, or thrombi. When transitioning from DAPT to single antiplatelet therapy (SAPT), previous studies have highlighted the risk of a rebound effect, defined as a statistical increase in inflammation and platelet adhesion. In this study, scientists did two experiments comparing platelet and inflammatory cell adhesion on different types of stents implanted in pigs after DAPT and SAPT. They found no evidence of rebound effect after the transition from DAPT to SAPT. The fluoropolymer-coated everolimus-eluting stent (FP-EES) delivered the most beneficial antithrombotic and anti-inflammatory effects.

Read about it here, in the journal Catheterization and Cardiovascular Interventions.